In demonstrating the proteids of food as the normal, and therefore the most constant factor in the production of indol, one must not overlook the disintegration of albuminoid tissue. To do so would be a serious omission, for the recognition of an intense indican reaction as a valuable aid in diagnosis, and its general adoption as such by the medical profession must rest largely upon its relation to suppuration and allied degenerative processes, as in the necrosis of syphilis or carcinoma. Indol is set free whenever any of the following processes exist: 1. Suppuration in a closed cavity. 2. Continued suppuration with a free outlet. 3. Ulceration or necrosis of tissue.
As regards the intensity of an indicanuria from either of the first two causes, three factors must be considered: a, the length of time in which the purulent fluid has been secreted; b, the adaptability of the enclosing surfaces
VAUX FL. INDOL: ITS RELATION TO PROLONGED SUPPURATION AND LARDACEOUS CHANGE. JAMA. 1898;XXXI(5):203–208. doi:10.1001/jama.1898.92450050001001
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