Existing evidence points strongly to the fact that acute endocarditis is an infectious disorder of varying degree of severity, dependent probably upon a multiplicity of different micro-organisms. Of the diseases with which acute endocarditis is associated or that it complicates, acute rheumatism is the most common. although it must not be overlooked that the inflammation of the endocardium may be an accompaniment of any one of a number of other infectious processes, and possibly it may be the sole obvious manifestation of such a process. While there is as yet no agreement as to the bacteriology of acute rheumatism, it is generally admitted that the disease is of bacterial origin, and it is to be inferred that the primary morbid process and its secondary complications are dependent upon the same etiologic factors. Now, while we have in the salicylates an almost specific remedy in the treatment of acute rheumatism, it
THE PROPHYLAXIS AND TREATMENT OF RHEUMATIC ENDOCARDITIS. JAMA. 1901;XXXVII(23):1537–1538. doi:10.1001/jama.1901.02470490035005
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