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December 14, 1901


Author Affiliations


JAMA. 1901;XXXVII(24):1597-1601. doi:10.1001/jama.1901.62470500025002j

The investigations of the last decade upon immunity to the infectious diseases have led to the discovery of many important and interesting facts. Among the most instructive of these we may mention the successful immunization of animals to serpent's venom achieved by Wolfenden, Phisalix and Bertrand, and Calmette, and the discovery in the blood of the immunized animals of a specific protective substance, first demonstrated by Phisalix and Bertrand, and elaborately studied by Calmette and Fraser.

THE METHOD OF IMMUNIZATION  adopted by Calmette consisted in the administration to horses of progressively increasing doses of cobra venom, slightly modified by heat, until the animals attained a high degree of immunity and antivenene appeared in large quantity in the blood.

COMPOSITION OF VENOM.  It has been well known for many years that the venom of serpents is not a simple poison, but one composed of several distinct poisonous proteids of different physiologic

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