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Article
December 14, 1901

THE ETIOLOGY OF HAY FEVER.

JAMA. 1901;XXXVII(24):1613. doi:10.1001/jama.1901.02470500041010
Abstract

The popularly accepted theory of the etiology of hay fever places the responsibility for this annoying disease upon vegetable pollen. The exact manner in which pollen causes hay fever does not seem to be cleared up. Recent investigations by Heymann and Matzuschita1 are calculated to throw some doubt upon the correctness of the pollen theory, because in a careful examination of the nasal contents of several hay fever sufferers, they failed to find much if any pollen present. They point out further that in certain experiments by Blackley and others only temporary irritative phenomena were induced by the introduction into the nose of much larger quantities of pollen than ever can take place under natural conditions, because the quantity of pollen in the air at the most suitable season and in the most suitable places is not very great. Heymann and Matzuschita made the observation that the number of

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