It has long been known that each tissue selects from the blood or serum brought to it the pabulum necessary for its existence and activity, and gives back the products of its metabolic metamorphosis. It is, however, only within quite a recent period that special importance has been attached to the so-called internal secretions, namely, the hypothetic products of the ductless glands, such as the thyroid, the adrenal, the spleen. The question has further arisen whether even organs provided with excretory ducts may not generate internal, in addition to their external, secretions. As a result of the interest that the subject has aroused and the important problems that are bound up with it, its study has naturally received a generous share of attention.
It is currently believed that myxedema is due to the suppression of the internal secretion of the thyroid gland, and that the symptom-complex known as Addison's disease
ADRENAL DIABETES. JAMA. 1901;XXXVII(26):1722–1723. doi:10.1001/jama.1901.02470520008003
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