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December 28, 1901


JAMA. 1901;XXXVII(26):1723. doi:10.1001/jama.1901.02470520009005

The normal amber color and transparency of urine may be changed as a result of alteration in concentration, in temperature, and in chemical constitution. The color may, further, be profoundly influenced by the ingestion of certain substances, such as rhubarb, santonin, gamboge and methylene-blue, and from the presence of certain morbid conditions, such as melanotic new growths, pernicious anemia and intestinal obstruction. Indican is by no means a rare constituent of urine, but indigo, in amounts sufficient to give the urine a distinct bluish coloration, is not so often observed. A case of this latter kind has recently been reported by A. McPhedran and William Goldie.1 The patient was a man, 24 years old, of sedentary habits and sallow complexion, who complained of weakness and heaviness of the lower extremities, palpitation of the heart, dull headache, and an inaptitude for work. He smoked heavily and ate irregularly and rapidly. The