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Since the systematic description by Banti in 1894 of a symptom-complex comprising enlargement of the spleen, associated with anemia, and later the development of ascites, the name Banti's disease has been applied to this disorder. Three stages in the progress of the affection are distinguished: 1, an anemic stage, characterized by enlargement of the spleen and anemia, and lasting from three or four to ten or eleven years; 2, a transitional stage, of uncertain duration; and 3, an ascitic stage, which usually terminates fatally in from six months to a year. In Banti's opinion, the spleen is the primary seat of the disease, toxic substances being generated in it as a result of some hypothetic infectious process, entering the circulation and causing anemia, and, by passing through the liver, causing hyperplasia of the interstitial connective tissue. It has, further, been suggested that the toxic substances may be derived from the
SPLENIC ANEMIA WITH ASCITES.. JAMA. 1902;XXXVIII(2):111–112. doi:10.1001/jama.1902.02480020041010
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