Addison was the first, in 1855, to point out the great importance of the adrenals to the animal economy, showing that the disease now bearing his name was due to lesions, usually tuberculosis, of these bodies. The following year Brown-Séquard demonstrated experimentally that these glands: "1, are essential to life; 2, that they modify or destroy a substance which otherwise transforms itself into pigment; 3, that when the organs are destroyed or removed this substance collects in the blood; 4, that removal is rapidly fatal, and injection of the blood of an animal thus treated into a healthy animal leads to symptoms like those of removal." Gratiolet, Phillipeaux and Harley disputed these findings, but Brown-Séquard by another series of experiments showed that his previous conclusions were correct. Brown-Séquard's conclusions were a little later confirmed by Tizzoni. Vulpian and Virchow also in 1856 showed that a reducing agent was contained in
HOUGHTON EM. THE PHARMACOLOGY OF THE SUPRARENAL GLAND AND A METHOD OF ASSAYING ITS PRODUCTS. JAMA. 1902;XXXVIII(3):150–153. doi:10.1001/jama.1902.62480030008001b
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