Over forty-five years ago Addison directed attention to the relation between a disease bearing his name and certain changes in suprarenal glands. Since then many able investigators studied the nature of this interesting organ and have established beyond doubt that the suprarenal glands possess a marvelous therapeutic value.
The principal investigators in the line of the use of the therapeutic properties of the glands are Brown-Sequard, Oliver, Schafer, Pellacani, Foa, Vincent, Cybulski, Bates, Moore, Swain, Solis-Cohen, Mayer, Reichert and others.
Since the therapeutic value became known many attempts to isolate the active principle of the glands have been made by several physiological chemists. Among these we may mention Prof. J. J. Abel of Johns Hopkins Hospital, Dr. B. Moore of London University and Dr. O. v. Furth of Strassburg.
Professor Abel published the result of his investigation first in 1897. Subsequently, two or three papers on the same subject were
TAKAMINE J. THE BLOOD-PRESSURE RAISING PRINCIPLE OF THE SUPRARENAL GLAND. JAMA. 1902;XXXVIII(3):153–155. doi:10.1001/jama.1902.62480030011001c
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