The more or less sudden appearance of edematous swellings in various parts, most frequently in the subcutaneous tissue, in persons with "nervous" tendencies, has led to the establishment of angioneurotic edema. As indicated by the name it is thought that the underlying condition is some form of disturbance in the innervation of the blood vessels. Kohn1 reports a case and reviews the literature. In Kohn's case the dipping of the hands in hot water brought on the edema; in previous cases the influence of cold in bringing on the circumscribed edematous swellings has been noted. Alcohol, trauma and malaria have also been regarded as of etiologic importance. In not a few cases the disease has manifested a distinct tendency to appear in families, affecting various members and generations of the same family. Associated pathologic conditions are usually not apparent, the swellings being recurrent and transitory. As indicated, they usually
ANGIONEUROTIC EDEMA.. JAMA. 1902;XXXVIII(3):179–180. doi:10.1001/jama.1902.02480030037006
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