Changes of some kind have been found in the pituitary body in all cases of acromegaly, in which there could be no doubt about the diagnosis, and in which a careful macroscopic and microscopic examination of the hypophysis was made. This is conceded by almost all writers who have contributed to our knowledge of the subject. Some, however, claim that the enlargement of the hypophysis is but one of the effects of the malady, something similar to the enlargement of the spleen, for instance, which has been found so often in acromegaly. They forget that in many cases we find not a simple hypertrophy or hyperplasia of the gland, but a malignant growth which does not in any way resemble the simply hypertrophic tissues found in other parts of the body. They also forget the fact—impossible of explanation if their view were correct—that in very nearly all acute cases of
KUH S. TREATMENT OF ACROMEGALY WITH PITUITARY BODIES.. JAMA. 1902;XXXVIII(5):295–299. doi:10.1001/jama.1902.62480050009001c
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