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February 8, 1902


JAMA. 1902;XXXVIII(6):401-402. doi:10.1001/jama.1902.02480060039003

From time to time cases are being reported in the literature which appear like typical typhoid from the clinical standpoint, but in which the blood serum does not develop the power of agglutination of typhoid bacilli. Observations of this kind heretofore have been reported as proving that too much reliance can not be placed upon the diagnostic value of the agglutinative reaction, especially when the result is negative. But as has been pointed out before in these columns, in patients with the clinical symptoms of typhoid fever bacteriological examination of the blood has resulted in a few instances in cultures of bacilli differing in essential respects from the bacillus of typhoid fever. Such cases have been described by Gwyn, Kurth, Schottmüller; and others have recorded more or less similar observations. In these cases the serum reaction was negative in the case of typical typhoid bacilli, but positive with the bacilli