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February 15, 1902

THE PROBLEMS OF SERUM-THERAPY.

JAMA. 1902;XXXVIII(7):435-437. doi:10.1001/jama.1902.62480070001001

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Abstract

With the advance of our knowledge of immune serums the evidence becomes more and more convincing that they operate chemically to produce their effects. So long as we conceived that their introduction into an animal was succeeded by a general vital reaction by means of which the cells received some kind of invigoration or rejuvenation, the conditions under which the serums operated were so occult that it seemed impossible to attain positive information about them.

The recognition of the chemical nature of the reaction, and the discovery that the laws governing it are not unlike laws governing other reactions with which we are familiar, together with the discovery that the toxin-antitoxin reaction is but one of a large series of vital reactions, has opened the way to new applications of serums in practice, and has suggested entirely new lines of research.

It will be remembered by those who are familiar

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