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Article
February 15, 1902

DIABETES FROM INJECTION OF ADRENALIN.

JAMA. 1902;XXXVIII(7):465-466. doi:10.1001/jama.1902.02480070031011
Abstract

The suprarenal gland has long been an organ full of mystery. The preparation of the active substance or substances of this gland known as adrenalin (Takamine) is endowed with powerful properties. Recently Herter and Richards1 showed that the injections into the abdominal cavity of dogs of adrenalin solution, 1 in 1000, in doses of from 6 to 10 c.c., in each instance produces well-marked glycosuria. In one instance the sugar appeared in the urine in less than five minutes after the injection. Blum, Luelzer and Croftan all found that the suprarenal gland had some influence upon carbohydrate metabolism. Croftan2 concluded that the glycosuria observed by him depended upon a ferment in the suprarenal gland which changes the glycogen of the liver into sugar. But Herter and Richards show that boiling the adrenalin solution for five minutes, which would be expected to destroy any diastatic ferment, does not suspend

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