Malignant disease of the penis occurs almost invariably as epithelial carcinoma and begins with about equal frequency on the inner surface of the prepuce or upon the glans.
According to Jacobson, its mode of commencement is varied. It appears most frequently as: 1. A wart or warty excrescence. 2. Sometimes, however, it makes its appearance as a small nodule or knot of induration under the surface of the mucous membrane. 3. Again, epithelioma is observed occurring under the form of a superficial excoriation or raw patch, resembling the erosions found in balano-posthitis. 4. It may develop as an ulcer resulting from the transformation of a chancroid or the breaking down of an old cicatrix, or sometimes from a crack or tear on the margin of a tight foreskin.
In cases of extreme rarity epithelioma of the penis develops from the extension of the malignant process outwards from the urethra or
MORTON HH. CANCER OF THE PENIS.. JAMA. 1902;XXXVIII(8):499–501. doi:10.1001/jama.1902.62480080009001a
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