Since the work of Bouchard showed so clearly the toxicity of the substances normally eliminated by the kidneys, and retained under conditions of renal insufficiency, other possible agencies in the production of the condition resulting from such renal insufficiency have been overshadowed and lost from view. Recent studies of the functions of the kidney that are other than eliminative lead to a reconsideration of the subject, and suggest that perhaps after all the retention of normal metabolic products is not the only factor, possibly not the chief one. That the kidney produces an internal secretion that is of further use within the body is scarcely to be doubted, a priori. Probably among the products of cell activity in every tissue are some substances that are available, if not essential for other tissue cells. In the kidney, however, the excretory function is so prominent that its other possible functions have escaped
ORGANO-THERAPY IN UREMIA.. JAMA. 1902;XXXVIII(8):517. doi:10.1001/jama.1902.02480080027004
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