One of the most interesting practical advances in our knowledge of disease in recent years has come from the gradual development of the doctrine that internal viscera are often affected by the same virus that causes cutaneous eruptions. Until within the last ten years it was the custom to consider skin diseases under ordinary circumstances independent of internal organic affections. The discovery that certain skin lesions such as peliosis and purpura were evidently of rheumatic origin and that even such ordinary skin diseases as roseola, urticaria, erythema and certain forms of herpes were so frequently associated with rheumatism as to be surely connected with it etiologically was the first definite advance in knowledge that pointed out the intimate relation of the skin to affections of organs deeper seated.
More recently Osler described various visceral complications that occur with erythema multiforme. At Heubner's clinic in Berlin it was noted that an
SKIN ERUPTIONS AND VISCERAL LESIONS.. JAMA. 1902;XXXVIII(8):517–518. doi:10.1001/jama.1902.02480080027005
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