The examination of the blood of typhoid patients for the presence of typhoid bacilli at first gave exceedingly variable results, and there was a time when but little earnest work was done in this field. Of recent years, however, the systematic examination of the blood by cultural methods has been taken up anew by many investigators, and their results seem to have established definitely that the typhoid bacillus frequently exists in the blood in typhoid fever; indeed, it seems probable that it is present at some time in every case. The occurrence of typhoid bacilli in the rose-spots, in urine and in the various post-typhoid suppurative foci can be explained only upon the grounds that bacilli are carried by the blood. Furthermore, the existence of clinical typhoid fever, without the existence of typhoid intestinal and other lesions, and due apparently to a pure typhoid septicemia, shows that typhoid bacilli may
TYPHOID BACILLI IN THE BLOOD OF TYPHOID PATIENTS.. JAMA. 1902;XXXVIII(9):586–587. doi:10.1001/jama.1902.02480090038005
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