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Article
March 8, 1902

POISONS AND DEFECTIVE RENAL ELIMINATION.

JAMA. 1902;XXXVIII(10):652. doi:10.1001/jama.1902.02480100028010
Abstract

In cases of diseased kidneys where elimination through the renal secretion is more or less interfered with, it has usually been stated that poisonous medicines should be administered with more than usual caution for fear that they might accumulate in the blood and cause fatal effects. Such statements have generally been founded upon theoretical and not experimental considerations. For a long time opium was withheld in cases of uremia and other conditions associated with diseased kidneys because of fear that the lessened elimination would lead to poisonous results from the accumulation of the drug in the body. Although Loomis was not the first to employ hypodermic injections of morphin for the cure of uremic convulsions, it was he who especially pointed out the value of such treatment, and his advocacy of it has been largely instrumental in leading to its general adoption. Most clinicians now employ morphin in uremic convulsions

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