Since I had seen a very instructive case of combination of carcinoma of the stomach and chronic round ulcer, in November, 1893, it has always seemed to me that the stomach is the organ most suited for the study of the origin and development of carcinoma.
The case referred to was observed clinically from 1893 to 1895, when the patient died, and the postmortem examination revealed, in the pyloric region, a large ulcer, the lower edge of which was carcinomatous, while the mucous membrane and the upper edge showed no carcinomatous degeneration whatsoever. The difference between the condition of the two edges of the ulcer was too striking to be ignored, and caused me to give further thought to the matter. It then occurred to me that only mechanical influences could explain the different conditions of the two edges of the ulcer. The mechanical factors coming here into play are,
FUETTERER G. THE ORIGIN OF CARCINOMA OF THE STOMACH FROM CHRONIC ROUND ULCER OF THE STOMACH. JAMA. 1902;XXXVIII(11):693–699. doi:10.1001/jama.1902.62480110011002b
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