The diagnosis of tumor of the brain may be easy or difficult, in accordance with the situation and the mode of growth of the neoplasm. The difficulties are greatest when it is situated in the so-called silent or latent areas of the brain, but invasion even of these often gives rise, as increasing experience is showing, to characteristic symptoms, whose significance we are only beginning to appreciate. This is particularly true of the prefrontal lobe, lesions of which, while usually unattended with motor manifestations, give rise to peculiar mental disturbances. These consist in loss of self-control and a subsequent change in character, with errors in judgment and reasoning. There is inability to fix the attention, to follow a continuous train of thought or to conduct intellectual processes. Sometimes also the gait is staggering, like that of cerebellar disease.
A case illustrating the localizing value of the symptom-complex under consideration and
SYMPTOMATOLOGY OF LESIONS OF THE PREFRONTAL LOBE.. JAMA. 1902;XXXVIII(11):710–711. doi:10.1001/jama.1902.02480110032003
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