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Article
March 15, 1902

ARSENIC AS A NORMAL CONSTITUENT OF TISSUES.

JAMA. 1902;XXXVIII(11):711. doi:10.1001/jama.1902.02480110033004
Abstract

Gautier's discovery that minute quantities of arsenic can be detected in perfectly normal tissues of human beings who have not taken arsenic knowingly, has attracted much attention, especially because of the short time that had elapsed since Baumann's discovery of iodin in the thyroid. The interesting deductions that Gautier made, also did much to arrest attention. Briefly, Gautier's1 results were as follows: By using 100 grams or more of the substance to be tested minute quantities of arsenic could be detected in many tissues. The thyroid gland contained the most, about 0.75 milligram per 100 grams. Next to that came the mammary gland, with 0.13 mg. The brain contains variable quantities, usually more than the thymus, which in turn contains more than the skin and its appendages in which traces are constant. A great many other tissues that were examined showed no arsenic, among which was the hypophysis, strangely

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