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Three years ago, at a meeting of this body in Baltimore, a paper was read upon a similar subject by a distinguished surgeon. In that paper, based upon a personal experience of nine cases, three of which were carcinoma and a large proportion of the remainder types of sarcoma, which I had myself regarded as unfavorable, the broad generalization was made that the method was of no value, and the prophecy was ventured that in one year from that date it would be forgotten and buried in that oblivion that has furnished a quiet resting-place for so many of the brilliant cancer cures that have from time to time dotted the medical history of the past.
In the discussion of the paper I was rash enough to dissent from these conclusions, and in spite of the warnings and criticisms of the skeptics, I have steadily presevered along the same lines,
COLEY WB. THE TREATMENT OF INOPERABLE SARCOMA WITH THE MIXED TOXINS OF ERYSIPELAS AND BACILLUS PRODIGIOSUS. IMMEDIATE AND FINAL RESULTS IN ONE HUNDRED AND FORTY CASES. JAMA. 1898;XXXI(8):389–395. doi:10.1001/jama.1898.92450080015001d
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