The close study of cases of disease which have at first appeared to be identical has often led to a separation of the original clinical entity into two or more distinct diseases each having its own peculiarities. Since Bretonneau wrote his classical memoirs on diphtheria this disease has been recognized as one entirely separate from other pseudo-membranous inflammations of the throat, and with the aid of modern bacteriologic methods the differentiation of the various forms of angina upon an etiologic basis has been carried still further. Exhaustive study has always been fruitful in the separation of diseases which were previously confused. On the other hand, the thorough study of individual clinical diseases has often resulted in the discovery that what had appeared to be entirely different conditions may have much in common and may even be different phases of the same general disease. This is exemplified in a group of
FAMILY PERIODIC PARALYSIS AND ALLIED NEUROSES.. JAMA. 1902;XXXVIII(13):826. doi:10.1001/jama.1902.02480130024003
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