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For a long time the appendix and adjacent parts were distinguished as being the only structures in the human body where the known presence of pus was not an indication for its removal. Ignorant of the etiology and pathology of the inflammatory diseases of this region, restrained by exaggerated ideas of the hazards of intra-peritoneal surgery, few surgeons had the courage to oppose this violation of a generally recognized law; and for many years, under various names, appendicitis received only those treatments that were purely medicinal, symptomatic and palliative, while the results depended alone upon the unaided reparative efforts of nature.
But since the pathologist has conclusively proven that from the very nature of the disease, neither internal medications nor external applications can have any direct effect upon this disease, and that all clinical evidence to the contrary must of necessity be deceptive, and since modern methods and perfected skill
NILES HD. THE TIME TO OPERATE IN APPENDICITIS. JAMA. 1898;XXXI(9):454–456. doi:10.1001/jama.1898.92450090020001f
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