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April 26, 1902


JAMA. 1902;XXXVIII(17):1085. doi:10.1001/jama.1902.02480170039007

In The Journal of March 23, 1901, page 820, appears an editorial abstract of the work of Frenkel and Cluzet on the reaction with sulphur for the presence of biliary acids in urine and other fluids. "When sublimed sulphur—flour, or flowers, of sulphur—is added to urine containing bile, the sulphur immediately falls to the bottom." This reaction they termed Haycraft's reaction for bile, this being the name mentioned in connection with the reaction in Langlois and de Varigny's physiology. But it appears that the actual author of the reaction is Matthew Hay, professor of legal medicine in Aberdeen, and in a recent note Frenkel1 makes the necessary correction. Professor Hay in 1886 inserted a note, describing the reaction in the second English edition of Landois' physiology, translated by Stirling (page 381), but the test was not described in the journals. Consequently the sulphur reaction for biliary acids should be