It does not seem unreasonable to hope that in the progress of time we may be provided with sera or antitoxins for the treatment of the various self-limited infectious diseases. Notwithstanding industrious examination, the exciting factors of the exanthematous diseases have as yet eluded detection. Until these are known it will be impossible to establish immunity artificially in such a way as to permit of the production of agents possessed of specific curative properties. Inasmuch, however, as the diseases under consideration terminate spontaneously, probably as a result of the generation and action within the body of antitoxic substances, and as one attack usually confers immunity against subsequent attack, it has been thought that curative effects could be obtained by the employment of the blood-serum of those convalescent from those diseases. Observations along this line have been made for several years at the clinic of Ernst von Leyden1 in Berlin
THE TREATMENT OF SCARLET FEVER WITH THE BLOOD-SERUM OF CONVALESCENTS.. JAMA. 1902;XXXVIII(18):1165. doi:10.1001/jama.1902.02480180043011
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