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Whatever interest the manifold substitutes for iodoform may have for the surgeon or dermatologist, they are too similar in chemical construction and attributes to claim the serious attention of the scientific pharmacologist familiar with the laws of the relationship between chemical constitution and physiologic activity; the latter knows that clinically they must be of practically identical worth and have all the same limitations, disadvantages or dangers. Surgeons employ the odoriferous, toxic, non-antiseptic iodoform in the treatment of infected wounds because they know that not one of the substitutes is of equal value in cleaning the wound of the products of septic and necrotic processes and in stimulating healthy granulation. Aside from the stigmatizing odor of iodoform, the need of a substitute therefor has received additional emphasis by the fact that within comparatively recent times surgeons everywhere have frequently recorded more or less severe forms of headache, with or without anuria
BARNES AC, HILLE H. A NEW DRY SURGICAL DRESSING. JAMA. 1902;XXXVIII(19):1207–1208. doi:10.1001/jama.1902.62480190013001b
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