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May 17, 1902


JAMA. 1902;XXXVIII(20):1306. doi:10.1001/jama.1902.02480200020003

During recent years glycerinated vaccine lymph has come into general use and the results obtained with it have been so favorable that the older method has been almost entirely discarded. Some doubt has recently been thrown on the relative value and advantages of dried and glycerinated lymph, and it is well to bear certain facts in mind in arriving at any conclusions. It has been shown that the vaccine material as it comes from the animal, be it pulp or exuding serum, is practically never free from bacteria. These bacteria are often nonpathogenic, but in some instances infectious organisms are present, especially pyogenic bacteria. If the lymph is stored in a moist condition without the addition of preservatives, the bacteria originally present rapidly multiply to an enormous extent and destroy the virus. If the lymph is dried upon ivory points in the usual manner, it does not part with all