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May 17, 1902


JAMA. 1902;XXXVIII(20):1309-1310. doi:10.1001/jama.1902.02480200023009

Studies with the various serums and anti-serums have led to the demonstration that milk, human and otherwise, generally contains fibrin ferment. This fact is readily demonstrated by adding a drop or so of milk to hydrocele fluid, which contains fibrinogen but no fibrin ferment, and coagulation results. We owe this observation to Moro and Hamburger1 and Bernheim-Kauer.2 Hydrocele fluid may lose the property of coagulating after standing for some days and after heating for thirty minutes to 55-56 C. The ferments in various milks do not react alike to heating, that in cow's milk not being affected by so low temperatures as the ferment in woman's milk. Bernheim-Kauer sought to obtain an antibody for the fibrin ferment in human milk by repeated injections of rabbits with milk, and with success. By suitable experiments with this anti-serum he shows that the ferment in cow's milk is not identic with