Hematuria with no apparent or demonstrable cause has been the subject of considerable discussion, and one explanation for some of the cases was mentioned editorially1 in a recent issue.
L. G. Guthrie2 has reported a most interesting series of cases of hematuria occurring in two sisters and eight of their children. Blood was noticed in the urine soon after birth and persisted for years. The amount of blood was variable, sometimes being sufficient to impart a bright red color to the urine and again being recognized only by a microscopic examination. In all the cases there occurred paroxysmal exacerbations of the hematuria accompanied by slight pyrexia, malaise, headache, vomiting and slight pain in the back or limbs. These paroxysms could not usually be ascribed to any certain cause and occurred at night as well as during the day. None of the usual symptoms of nephritis were present. The
IDIOPATHIC OR CONGENITAL, HEREDITARY AND FAMILY HEMATURIA.. JAMA. 1902;XXXVIII(22):1446. doi:10.1001/jama.1902.02480220032009
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