Mixed infections are frequent in typhoid fever, and as this disease is the one disease above others that calls for the agglutination reaction as a diagnostic measure, it becomes of value to know what influence, if any, mixed infection may have on this reaction. Castellani2 studied this question experimentally. In one series of experiments he injected rabbits with two different, agglutinable bacteria at the same time, such as the typhoid bacillus and the colon bacillus, the typhoid bacillus and the bacillus of dysentery, etc. He found that the blood serum acquires agglutinating properties for all the bacteria injected, the time of appearance, intensity and duration of the agglutination of each bacillus being identic with the conditions observed when only one bacillus is injected. He then established a single infection to which there was added after a time a second infection and found that here also the agglutinative powers develop
THE DIAGNOSTIC VALUE OF AGGLUTINATION IN MIXED INFECTIONS. JAMA. 1902;XXXVIII(22):1448–1449. doi:10.1001/jama.1902.02480220034018
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