A tendency has grown up to look upon every infectious process as a constitutional disorder with local manifestations, whereas a little reflection will show that, as a rule, it is the opposite relation that prevails. Pathogenic agents that gain entrance into the body generally find lodgment at some point anatomically related to the channel of entry. Here, they are most likely to set up their peculiar morbid processes, from which, however, extension may take place by continuity or contiguity of tissue, or through the blood or the lymph vessels. In any event the individual lesions are essentially local, although they may not be circumscribed, but rather diffuse or disseminated in distribution. Whether the one or the other, the poisonous products resulting from the reaction between the invading micro-organisms and the attacked tissues are distributed through the circulation and reach all parts of the body, thus giving rise to the constitutional
THE LOCALIZATION OF TUBERCULOUS INFECTION.. JAMA. 1902;XXXVIII(22):1449. doi:10.1001/jama.1902.02480220035020
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