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June 7, 1902


JAMA. 1902;XXXVIII(23):1518. doi:10.1001/jama.1902.02480230046006

The interest in the relation of diabetes to lesions in the pancreas has been much increased by the recent demonstration of more or less definite changes in the so-called islands of Langerhans in many cases of this disease. The final explanation of diabetes must be sought by chemical methods, and the recent work of Herter and others on adrenalin diabetes, to which reference has been made in these columns from time to time, is extremely suggestive and important. In the meantime the finer morphologic changes that there is good reason to believe may constitute the anatomic substratum of spontaneous pancreatic diabetes will appeal to many as an interesting field of research. No doubt many facts of value will accumulate in time from investigations in this line.

At present interest centers especially in the islands of Langerhans, these peculiar glomerulus-like, minute structures that have the same general cellular make-up in the