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June 7, 1902


JAMA. 1902;XXXVIII(23):1520. doi:10.1001/jama.1902.02480230048012

There have been reported in recent years a small number of cases characterized by undue readiness of fatigue in certain groups of muscles, especially those supplied by the bulbar nerves, occurring in attacks, without alteration in sensibility, in nutrition and in reflex activity. The irritability of the affected muscles is, further, quickly exhausted by electric stimulation, constituting the myasthenic reaction. The nature of these cases is obscure and in the absence of more definite knowledge and of evidence of organic disease they have been thought to be of toxic origin. That they may be of varied pathology is suggested in a recent communication by Dr. Jeno Kollarits,1 who reports two cases presenting typical symptoms of myasthenia, also a case of cerebellar tumor studied clinically, one of cerebellar tumor and sarcomatous infiltration of the spinal pia mater with postmortem examination, and one of exophthalmic goiter, in all of which the