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The history of serum therapy is like the history of a day—a busy day—into which is crowded the memory of a thousand conflicting incidents, all so brief and fleeting in character as to be almost forgotten on the morrow. Many of us remember the "good old days" of thumb lancet and fever starvation, when serum therapy was not even a dream; most of us remember when the clouds first began to separate under the influence of scientific research, and all of us remember when the first sunbeam of actual discovery burst upon the world like a meteor's gleam. It must not be inferred from this that no hint of the underlying principles of serum therapy was ever scented until the present generation, for a suggestion of them was made nearly two hundred years ago, when the Turks are credited with practicing a crude form of inoculation against smallpox. The methods
COX GW. PRESENT STATUS OF SERUM THERAPY. JAMA. 1898;XXXI(15):829–834. doi:10.1001/jama.1898.92450150015001g
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