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Article
October 22, 1898

THE ESTIMATION OF URIC ACID IN URINE.

Author Affiliations

PHILADELPHIA, PA.

JAMA. 1898;XXXI(17):955-959. doi:10.1001/jama.1898.92450170009002

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Abstract

While connected with the Stetson Laboratory of Hygiene, my attention was called to the fact that it was desirable to make a study of the conditions under which there was an increased, and other cases in which there was a decreased, elimination of uric acid. Intimately associated with this would be a physiologic study of tissues and probably also cell metabolism; in other words, determining the place occupied by uric acid in the chemistry of the animal body. The purely physiologic study being out of my line, I determined, on the recommendation of two of my former colleagues, Dr. Judson Daland and Dr. Frank Massey, to take up the purely chemic side of the question.

The first step in the investigation would be to determine on a method for the estimation of uric acid which would be comparatively simple in its application, and which would in the different operations be

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