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November 5, 1898


JAMA. 1898;XXXI(19):1117-1118. doi:10.1001/jama.1898.02450190043005

The essential lesion of contagious pleuro-pneumonia of cattle (a peripneumonia of the French) consists in the distention of the interlobular connective tissue spaces by a large quantity of inflammatory exudate. If a drop of this serum is inoculated into the subcutaneous tissue there will appear, after from nine to twenty five days, an inflammatory engorgement of varying dimensions, which is often followed by death, At the autopsy there is found a large quantity of yellowish serum in the tissue spaces, which is here and there coagulated into gelatinous masses. The exudation sometimes amounts to several liters. Animals that recover after a slight sickness of a few days become refractory to experimental inoculation as well as to natural contagion.

This fluid, so virulent for animals of the bovine species, is without action upon other species. These facts were, according to Nocard and Roux,1 demonstrated by Willems in 1850.

The demonstration