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November 5, 1898

WHY SHOULD WE ESTIMATE FOR UREA?

JAMA. 1898;XXXI(19):1120-1121. doi:10.1001/jama.1898.02450190046009

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Abstract

We have been taught that the excretion of uric acid to urea stands in the relation of 1 to 33. Haig states: "My researches have extended over a large part of the last twelve years, but taking only the figures of the longer periods of my estimation of my own excretion, we get a total of 2351 days, in which 28,447 gr. of uric acid, 805,432 gr. of urea and 127,725 of acid (reckoned as oxalic acid) were excreted, giving a relation of uric acid to urea of about 1 to 28, and a relation of acid to urea of 1 to 6.3."

If we desire to estimate the amount of uric acid in a given sample of urine, and turn to the process first devised by Hopkins, we might be astounded at the lengthened process necessary to obtain the amount of such a common ingredient as uric acid. Indeed,

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