Although acromegaly was first described as a medical entity in 1886, since that time (Woods Hutchinson) two hundred and fifty cases have been reported, of an average of about twenty per year. When it is taken into account that probably at least one-half of these reported cases, like the one herewith submitted, were recognized, although not classified, before Marie brought the subject into prominence, it may not be deemed unreasonable to say that, the world over, ten represents the number of cases annually developing into the malady of acromegaly, and that it is, therefore, one of the rarest diseases known. The subject of acromegaly has been scientifically presented by numerous investigators quite recently, a list of several of the latest of these papers being found at the close of this report, and for the purpose of increasing the number of reported cases and to enhance the value of the more
COE HW. A CASE OF ACROMEGALY. JAMA. 1898;XXXI(23):1347–1348. doi:10.1001/jama.1898.92450230019001g
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