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December 17, 1898


JAMA. 1898;XXXI(25):1485. doi:10.1001/jama.1898.02450250043007

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The relation of uric acid to neurasthenia has been long ago suggested, but has not entered definitely into the pathology of the disorder. Ordinarily we are or have been inclined to accept the action of the fatigue and exhaustion of the nerve-cell as the principal factor in its production without specially looking further for the influence of morbid metabolism in its production. Nevertheless, in these days, when auto-intoxication is invoked so often as a cause of disease, neurasthenia could not well be overlooked, and certain French authorities, notably among them Vigouroux, have maintained that neurasthenia and the arthritic diathesis are closely connected, if not merely differing manifestations of the same general disorders of oxidation and tissue change. In this country we have recognized a disorder the majority of the symptoms of which are essentially neurasthenic—lithemia, as the common American manifestation of the gouty constitutional vice—thus admitting, to a certain extent

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