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The increasing knowledge of pathologic anatomy and pathogenic physiology tends to evolution in therapeutics affecting our remedial agents. We discover that they have more or less definite value; they have their rise and fall. The drug extolled today by high authority we find does not come up to the manifesto of the manufacturing chemist and may be obsolete tomorrow. When antifebrin was first introduced, a child was brought from New York City for treatment. Their physician had prescribed this drug in 2-grain doses, to be given every two hours if there should be a rise in temperature. After they had given it for a couple of days, the nurse noticed cyanosis and coldness of the extremities, with failing pulse. This fact was a valuable one to us. It is now found to have its effect as an antipyretic by depressing the heart, it has a directly paralyzing action upon the
NEWTON CB. AUTO-INFECTION AND PATHOGENIC PHYSIOLOGY. JAMA. 1898;XXXI(26):1514–1516. doi:10.1001/jama.1898.92450260018002d
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