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February 18, 1899


JAMA. 1899;XXXII(7):376-378. doi:10.1001/jama.1899.02450340044009

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Until very recent years the tendency of medical teaching has been to assign all forms of leukemia to the realm of chronic diseases. A case of leukemia running a course of about six weeks, reported by Fraenkel almost half a century ago, received but little attention at the time. Succeeding this case there appeared from time to time reports from other sources, describing practically identic cases both as regards symptoms, including blood count, and pathologic lesions appearing at autopsy. A little over ten years ago these cases were collected by Ebstein, and from this date we must look upon this rapidly fatal form, acute leukemia, as classified as a distinct disease. During the last decade so much has been added to our knowledge of all forms of leukemia, and because of this, descriptions of the disease have changed so much, that the separation of the varieties has been almost too

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