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The occurrence of jaundice at some period during the course of many of the infectious diseases is a matter of common observation. Of these, malaria, particularly the estivo-autumnal variety, typhoid and typhus fevers, yellow fever, and the septic processes, septicemia and pyemia, offer the usual and typic examples. For convenience of classification it has been the custom to divide the ordinary forms of jaundice into two classes: 1. The hematogenous, which occurs when the specific germ or the products of its manufacture causes such excessive destruction of the red blood elements that the liver is totally unable to perform the increased amount of work imposed upon it, that the product of this red corpuscular destruction, bilirubin, becomes to some extent reabsorbed by the lymph and blood-vessels, and the characteristic discoloration follows. In these cases, and this fact is an important one, the urine contains but little bile pigment, and the
JAUNDICE IN ACUTE INFECTIONS. JAMA. 1899;XXXII(13):716. doi:10.1001/jama.1899.02450400034006
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