Homén and Laitinen1 injected virulent streptococci as well as their toxins into peripheral nerves and other parts of the nervous system, and carefully studied the resulting changes. They found that the first action of the bacteria and their toxins is a local one at the site of injection, consisting in a granular disintegration of the nerve-fibers, together with leucocytic emigration, and proliferation of the cells in the nerve-sheaths and the endoneurium. This process then progresses from the periphery toward the center, the bacteria being generally found at the border of the changed and relatively intact parts. When they are injected into the sciatic nerve, for instance, they sooner or later reach the spinal ganglia, where there is produced disintegration of the ganglionic cells or solution of their chromatophilic elements. At the same time there is a round-cell infiltration into the subdural sheaths and into the nerve-roots. In the spinal
ACTION OF STREPTOCOCCI AND THEIR TOXINS UPON NERVES AND SPINAL CORD. JAMA. 1899;XXXII(15):831. doi:10.1001/jama.1899.02450420039009
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