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Article
May 6, 1899

MULTIPLE PRIMARY CARCINOMA.REPORT OF TWO CASES.

Author Affiliations

INSTRUCTOR IN PATHOLOGY IN THE UNIVERSITY OF MICHIGAN. ANN ARBOR, MICH.

JAMA. 1899;XXXII(18):963-969. doi:10.1001/jama.1899.92450450003001a
Abstract

The relative rarity of multiple primary carcinoma has led to the production of a number of very important articles concerning their occurrence and origin. Winiwarter, Kaufmann, Michelsohn, Schimmelbusch, Bard and Bucher have especially busied themselves with this subject, and, from an exhaustive search of the literature and analysis of personal observations, have given us very important facts not only concerning the origin of multiple carcinomata but of carcinoma in general. To the number of cases of multiple primary carcinoma already reported and studied I shall add in this paper the reports of two cases, in each of which there were two undoubted primary cancers. These cases are important because they add new combinations to those already described, and also because they may serve to give some additional support to some of the theories of the origin of carcinoma.

Only those cases can be regarded as true multiple primary carcinomata in

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