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June 17, 1899


JAMA. 1899;XXXII(24):1393. doi:10.1001/jama.1899.02450510051015

Our knowledge of conditions attended with glycosuria has been much extended of late years through the observations, clinic and experimental, of a number of industrious investigators. As a result, the detection of sugar in the urine in any given case no longer causes the alarm and gives rise to the sense of hopelessness and the gloomy prognosis that were the rule in the past. It is recognized that glycosuria may be of various grades of intensity, and that diabetes may be mild or severe. The most serious complication of these metabolic disturbances is the intoxication that is directly the most common cause of death and that manifests itself clinically in the form of various nervous disturbances, and finally as coma. It has been thought that this condition is dependent on the presence in the blood of certain acids, and more particularly diacetic and β.-oxybutyric acids, and it has been suggested

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