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June 24, 1899


JAMA. 1899;XXXII(25):1452. doi:10.1001/jama.1899.02450520050009

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By acute infectious multiple neuritis we understand cases which begin and progress according to the type of an acute infectious disease. They are accompanied with more or less elevation of temperature, general malaise, headache, pains in the joints, swelling of the spleen, albuminuria and the characteristic nervous symptoms. Usually death soon results, often preceded by symptoms of asphyxia. Muscular changes are usually absent, on account of the rapidity of the course. From a pathologico-anatomic standpoint these cases are interesting, because there is found a genuine interstitial neuritis. The nerves appear swollen, grayish-red, and often are the seat of small hemorrhages. Occasionally the nerve appears nodular, on account of foci of cell accumulation and exudation. Microscopically there is marked congestion, perivascular round-cell infiltration, which extends in between the nerve bundles. In some cases the cellular exudation may be so intense that miliary abscesses are formed. At the same time, there is

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