It is not improbable that the symptom-complex clinically designated acute articular rheumatism is of multiple and varied origin, and it is not less improbable that the etiology of endocarditis is likewise not uniform. It is known, in fact, that both arthritis and endocarditis may arise in conjunction with a considerable number of infectious processes, and it is not surprising, therefore, that the course and termination of the two affections should vary accordingly. The endocardial lesions, further, may assume various forms, as indicated, for instance, by the pathologic qualifications verrucose, polypoid, villous, ulcerative, suppurative, and by the clinical qualifications benign and malignant. All of the differences hinted at must be attributed to variations in the etiologic factors, and many of the problems that are bound up with this interesting and complex subject must await their solution at the hands of the bacteriologist and perhaps of the physiologic chemist; and who knows
BENIGN AND MALIGNANT ENDOCARDITIS.. JAMA. 1899;XXXIII(10):609–610. doi:10.1001/jama.1899.02450620047005
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