No class of cases has stimulated a greater variety of methods for treatment than malignant disease of the genital organs, including the mammary gland. In combating this dreadful disorder medical and surgical therapeutics have been exhausted. In searching for new agencies it is not surprising, in this day of organotherapy, that the animal secretions and extracts should have found employment. Thyroid extract has found its advocates. The well-recognized, and frequently demonstrated influence of the ovaries on the circulation of the genital glands naturally led to the consideration of the influence of their ablation on the preexisting malignant disease.
To G. Thomas Beatson of England belongs the honor of being the first surgeon who deliberately removed the appendages for the relief of mammary cancer. The did, June 15, 1895, on a woman aged 33 years, from whom in the preceding January the entire breast, including the pectoral muscle and the
MONTGOMERY EE. DOES THE REMOVAL OF THE OVARIES EXERT BENEFICIAL INFLUENCE ON THE SUBSEQUENT PROGRESS OF MALIGNANT DISEASES?. JAMA. 1899;XXXIII(13):751–752. doi:10.1001/jama.1899.92450650001001
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